Just for fun and I'll go first, taking the easy way out.
Alien (1979)
Who wants B?
B's easy too
Back to the Future 1985
Close Encounters of the Third Kind (1977)
Fifth Element (does that count?)
Giant Gila Monster
The Jacket (2005)
Johnny Mnemonic ( i wanted to say Judge Dredd, but thats not totally sci-fi)
Okay someone got J as i was writing so
Killer Klowns from Outer Space
The Lawnmower Man
All right, super retro for M
Metropolis (1927)
Several movies I haven't seen in this list already. Very cool. And the Fifth Element totally counts, scareyworms. One of my favourites and certainly Bruce Willis' best (IMHO).
Night of the Comet
Outland
Primer
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